反应详情

To a stirred suspension of di-tert-butyl 4-ethylpiperidine-1,4-dicarboxylate (1.1 g, 3.7 mmol) in tetrahydrofuran (13 mL) was added lithium tetrahydroaluminate (1.0N solution in tetrahydrofuran, 15 mL, 15 mmol), and the mixture was stirred at ambient temperature for 6 hours. The mixture was diluted with a 1N sodium hydroxide solution (5 mL), filtered over Whatman filter paper, and the solids were washed with ethyl acetate (50 mL). The combined filtrate was separated, and the organic portion was dried over sodium sulfate, filtered, and concentrated in vacuo to afford the title compound as a white solid, which was used in the next step without any further purification (506 mg, 57%).

1. filtrationfiltered over Whatman
2. filtrationfilter paper
3. washthe solids were washed with ethyl acetate (50 mL)
4. customThe combined filtrate was separated
5. dry with materialthe organic portion was dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo