HCID 15949507, compound → HCID 57666161, compound

HRID 602964Notes

Reaction equation

HRID 602964 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]3[CH2:12][N:11]([C@@H:13]4[CH2:18][C@H:17]([NH2:19])[C@@H:16]([C:20]5[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=5[F:28])[CH2:15][CH2:14]4)[CH2:10][C:8]=3[N:9]=2)[CH2:3][CH2:2]1.O=C1C[C@H](NC(=O)OCC2C=CC=CC=2)[C@@H](C2C=C(F)C(F)=CC=2F)CC1>CO.[Pd]>[CH:1]1([C:4]2[N:5]=[CH:6][C:7]3[C:8](=[CH:10][N:11]([C@@H:13]4[CH2:18][C@H:17]([NH2:19])[C@@H:16]([C:20]5[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=5[F:28])[CH2:15][CH2:14]4)[CH:12]=3)[N:9]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 15949507HCID 15949507, compoundHCID 57462502HCID 57462502, compound

Product 1

HCID 57666161HCID 57666161, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of [(1S,2R,5S)-5-[2-cyclopropyl-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]amine described in Example 2 (30.0 mg) in methanol (6 mL) was stirred with 10% palladium on carbon (6 mg) for seven days and the resulting product was purified by preparative TLC (silica, 7:93 methanol/dichloromethane) to give the title compound. LC-MS 387.3 (M+1).

Workup

  1. customthe resulting product was purified by preparative TLC (silica, 7:93 methanol/dichloromethane)

Sources & evidence

ORD record
ord-cc6b6c7e027c410488572c49e491642b
Source dataset
uspto-grants-2011_03
Patent number
US07906649B2

Reaction notes

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