HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 15949507, compound → HCID 57666161, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 15949507 | HCID 15949507 | — |
| Reactant | HCID 57462502 | HCID 57462502 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 57666161 | HCID 57666161 | — |
Reaction Steps
A solution of [(1S,2R,5S)-5-[2-cyclopropyl-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]amine described in Example 2 (30.0 mg) in methanol (6 mL) was stirred with 10% palladium on carbon (6 mg) for seven days and the resulting product was purified by preparative TLC (silica, 7:93 methanol/dichloromethane) to give the title compound. LC-MS 387.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906649B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-cc6b6c7e027c410488572c49e491642b |
| Source note | uspto-grants-2011_03 |