反应详情

A solution of 5.0 g (29.1 mmol) of 3,5-difluorophenylacetic acid and a solution of 20 mL (80 mmol) of HCl in dioxane (4M) in 60 mL CH3OH was heated at reflux for 6 h. After cooling, the solution was concentrated and the residue poured into 200 mL of ether/ethyl acetate (1/1). The organic layer was washed with 20 mL of water, dried over Na2SO4 and concentrated to afford the title compound.

1. temperatureat reflux for 6 h
2. temperatureAfter cooling
3. concentrationthe solution was concentrated
4. additionthe residue poured into 200 mL of ether/ethyl acetate (1/1)
5. washThe organic layer was washed with 20 mL of water
6. dry with materialdried over Na2SO4
7. concentrationconcentrated