Dimethylamine → 3-(1-{1-[(4-chlorophenyl)(3-cyanophenyl)methyl]azetidin-3-yl}-2-fluoro-2-methylpropyl)-5-fluoro-N,N-dimethylbenzamide

HRID 602992Notes

Reaction equation

HRID 602992 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]#[N:35])[CH:29]=2)[N:9]2[CH2:12][CH:11]([CH:13]([C:18]3[CH:19]=[C:20]([CH:24]=[C:25]([F:27])[CH:26]=3)[C:21]([OH:23])=O)[C:14]([F:17])([CH3:16])[CH3:15])[CH2:10]2)=[CH:4][CH:3]=1.[CH3:36][NH:37][CH3:38]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]#[N:35])[CH:29]=2)[N:9]2[CH2:12][CH:11]([CH:13]([C:18]3[CH:19]=[C:20]([CH:24]=[C:25]([F:27])[CH:26]=3)[C:21]([N:37]([CH3:38])[CH3:36])=[O:23])[C:14]([F:17])([CH3:15])[CH3:16])[CH2:10]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 670553863-(1-{1-[(4-Chlorophenyl)(3-cyanophenyl)methyl]azetidin-3-yl}-2-fluoro-2-methylpropyl)-5-fluorobenzoic acid

Product 1

HCID 670553173-(1-{1-[(4-chlorophenyl)(3-cyanophenyl)methyl]azetidin-3-yl}-2-fluoro-2-methylpropyl)-5-fluoro-N,N-dimethylbenzamide

Procedure

Prepared from 3-(1-{1-[(4-chlorophenyl)(3-cyanophenyl)methyl]azetidin-3-yl}-2-fluoro-2-methylpropyl)-5-fluorobenzoic acid and dimethylamine according to the procedure described in Preparation 22; Mass Spectrum: m/e=522 (M+1, 35Cl), 524 (M+1, 37Cl).

Workup

  1. customdescribed in Preparation 22

Sources & evidence

ORD record
ord-5481455dd8854f2c803b3425103643e0
Source dataset
uspto-grants-2011_03
Patent number
US07906652B2

Reaction notes

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