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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 602992Generated: October 30, 2026

Dimethylamine → 3-(1-{1-[(4-chlorophenyl)(3-cyanophenyl)methyl]azetidin-3-yl}-2-fluoro-2-methylpropyl)-5-fluoro-N,N-dimethylbenzamide

https://huagongshe.com/reaction/602992

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylamineHCID 674—
Reactant3-(1-{1-[(4-Chlorophenyl)(3-cyanophenyl)methyl]azetidin-3-yl}-2-fluoro-2-methylpropyl)-5-fluorobenzoic acidHCID 67055386—
Product3-(1-{1-[(4-chlorophenyl)(3-cyanophenyl)methyl]azetidin-3-yl}-2-fluoro-2-methylpropyl)-5-fluoro-N,N-dimethylbenzamideHCID 67055317—

Reaction Steps

Prepared from 3-(1-{1-[(4-chlorophenyl)(3-cyanophenyl)methyl]azetidin-3-yl}-2-fluoro-2-methylpropyl)-5-fluorobenzoic acid and dimethylamine according to the procedure described in Preparation 22; Mass Spectrum: m/e=522 (M+1, 35Cl), 524 (M+1, 37Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07906652B2
Source datasetuspto-grants-2011_03
ORD IDord-5481455dd8854f2c803b3425103643e0
Source noteuspto-grants-2011_03