HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(3,4-dichlorophenyl)piperidine-4-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-((3,4-dichlorophenyl)carbamoyl)piperidine-1-carboxylate | HCID 9041882 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(3,4-dichlorophenyl)piperidine-4-carboxamide hydrochloride | HCID 54595048 | 176.8% |
Reaction Steps
To a solution of tert-butyl 4-{[(3,4-dichlorophenyl)amino]carbonyl}piperidine-1-carboxylate (3.0 g) in dichloromethane (15 mL) was added 4M HCl in dioxane (15 mL). The mixture was stirred at room temperature for 1 hour and then filtered to give the title compound as a white solid (2.2 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906645B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-8615b9f508144ffb93095bd1345c3394 |
| Source note | uspto-grants-2011_03 |