Hydrochloric Acid → N-(3,4-dichlorophenyl)piperidine-4-carboxamide hydrochloride

HRID 603239Notes

Reaction equation

HRID 603239 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>ClCCl.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([CH:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 9041882Tert-butyl 4-((3,4-dichlorophenyl)carbamoyl)piperidine-1-carboxylate

Product 1

HCID 54595048N-(3,4-dichlorophenyl)piperidine-4-carboxamide hydrochlorideYield 176.8%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 4-{[(3,4-dichlorophenyl)amino]carbonyl}piperidine-1-carboxylate (3.0 g) in dichloromethane (15 mL) was added 4M HCl in dioxane (15 mL). The mixture was stirred at room temperature for 1 hour and then filtered to give the title compound as a white solid (2.2 g, 100%).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-8615b9f508144ffb93095bd1345c3394
Source dataset
uspto-grants-2011_03
Patent number
US07906645B2

Reaction notes

Loading…