反应详情

A solution of 4-tert-butylmorpholine-2-carbaldehyde (154 mg) and N-(3,4-dichlorophenyl)piperazine-1-carboxamide (247 mg) in dichloromethane (20 mL) was stirred at room temperature under argon. Sodium triacetoxyborohydride (381 mg) was added and the mixture was stirred overnight. The reaction was quenched with water and partitioned between water and dichloromethane. The organic layer was washed with saturated aqueous sodium hydrogen carbonate and then brine, dried (Na2SO4), filtered and concentrated. The residue was purified on the Isco™ Companion (12 g column: 0-11% MeOH in DCM) to give the title compound as a white solid (75 mg).

1. customThe reaction was quenched with water
2. custompartitioned between water and dichloromethane
3. washThe organic layer was washed with saturated aqueous sodium hydrogen carbonate
4. dry with materialbrine, dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was purified on the Isco™ Companion (12 g column: 0-11% MeOH in DCM)