Hydrochloric Acid → 2-Fluoro-1-morpholinoethanone

Temperature

70 °C

A mixture of ethyl fluoroacetate (50 g, 472 mmol) and morpholine (82 g, 944 mmol) was heated at 70° C. for 20 h. After cooling to ambient temperature, the mixture was added to a stirred mixture of 2 N HCl (240 mL) and methylene chloride (200 mL) over 20 min. The organic layer was separated and the aqueous layer was extracted with dichloromethane (200 mL×2). The combined organic phase was dried over anhydrous MgSO4 and concentrated in vacuo to give 51.7 g (74.6%) of the title compound. 1H NMR (400 MHz, CDCl3) δ 4.96 (d, J=47.2 Hz, 2H), 3.70 (bs, 4H), 3.64 (bs, 2H), 3.47 (bs, 2H).

1. temperatureAfter cooling to ambient temperature
2. customThe organic layer was separated
3. extractionthe aqueous layer was extracted with dichloromethane (200 mL×2)
4. dry with materialThe combined organic phase was dried over anhydrous MgSO4
5. concentrationconcentrated in vacuo

ORD record

ord-249986486b9e46c89a94334a19bc14ce

Source dataset

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07906676B2