反应详情

Sodium borohydride is dissolved in 75 ml of ethanol, and the starting material (2-hydroxy-4-methoxyphenyl)phenylmethanone, dissolved in 5 ml of THF, is added dropwise over the course of about 10 min. The reaction mixture is stirred at room temperature for 1 h until all the sodium borohydride has been consumed. The solvent is removed in vacuo. The residue is partitioned in methyl t-butyl ether (MTBE)/water, and the aqueous phase is extracted a further 3 times with 50 ml of MTBE. The combined organic phases are dried over sodium sulfate, and the solvent is removed in vacuo.

1. additionis added dropwise over the course of about 10 min
2. customhas been consumed
3. customThe solvent is removed in vacuo
4. customThe residue is partitioned in methyl t-butyl ether (MTBE)/water
5. extractionthe aqueous phase is extracted a further 3 times with 50 ml of MTBE
6. dry with materialThe combined organic phases are dried over sodium sulfate
7. customthe solvent is removed in vacuo