反应详情

tert-Butyl (4-formylphenoxy)acetate (93.7 g, 0.40 mol) was dissolved in dry toluene (200 mL), added 4-fluoroaniline (38.1 mL, 0.40 mol) and p-toluene sulfonic acid (cat, ˜1 g). The mixture was refluxed in a Dean-Stark apparatus for 2 hours, cooled at an icebath and a precipitate was formed. The precipitate was filtered, washed with cold heptane and dried to afford the title compound.

1. temperatureThe mixture was refluxed in a Dean-Stark apparatus for 2 hours
2. temperaturecooled at an icebath
3. customa precipitate was formed
4. filtrationThe precipitate was filtered
5. washwashed with cold heptane
6. customdried