反应详情

tert-Butyl (4-formylphenoxy)acetate (17.4 g, 73.4 mmol) was dissolved in dry toluene (120 mL) and 4-chloroaniline (9.37 g, 73.4 mmol) was added. The mixture was refluxed in a Dean-Stark apparatus for 20 hours, cooled and concentrated under reduced pressure. Hexane was added and a precipitate formed. This precipitate was filtered, washed twice with cold hexane and dried. This afforded the title compound.

1. temperatureThe mixture was refluxed in a Dean-Stark apparatus for 20 hours
2. temperaturecooled
3. concentrationconcentrated under reduced pressure
4. additionHexane was added
5. customa precipitate formed
6. filtrationThis precipitate was filtered
7. washwashed twice with cold hexane
8. customdried