Water → HCID 25133043, compound

HRID 604249Notes

Reaction equation

HRID 604249 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]([CH3:32])=[C:9]([C:12](=[O:31])[C:13](=[O:30])[N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=3)[CH2:16][CH2:15]2)[C:10]=1[CH3:11])=[O:5])C.O>C(O)C>[CH3:11][C:10]1[C:9]([C:12](=[O:31])[C:13](=[O:30])[N:14]2[CH2:15][CH2:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[CH:21]=3)[CH2:18][CH2:19]2)=[C:8]([CH3:32])[NH:7][C:6]=1[C:4]([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 962WaterHCID 25133045HCID 25133045, compound

Product 1

HCID 25133043HCID 25133043, compoundYield 85.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 0.100 g (0.221 mmol) 3,5-dimethyl-4-{2-oxo-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-acetyl}-1H-pyrrole-2-carboxylic acid ethyl ester in 2 ml ethanol and 1 ml water 0.018 g (0.443 mmol) NaOH were added. The solution was stirred at 80° C. for 5 h. The solvent was evaporated and 1 N HCl was added to the residue. The precipitate was filtered off and dried to yield 80 mg (85%) of the title compound. MS 424.15 (M+H)+,

Workup

  1. customThe solvent was evaporated
  2. addition1 N HCl was added to the residue
  3. filtrationThe precipitate was filtered off
  4. customdried

Sources & evidence

ORD record
ord-6dc04f10f6754e27a55e712f4f3cd98d
Source dataset
uspto-grants-2011_03
Patent number
US07910576B2

Reaction notes

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