Water → HCID 25133043, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.100 g (0.221 mmol) 3,5-dimethyl-4-{2-oxo-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-acetyl}-1H-pyrrole-2-carboxylic acid ethyl ester in 2 ml ethanol and 1 ml water 0.018 g (0.443 mmol) NaOH were added. The solution was stirred at 80° C. for 5 h. The solvent was evaporated and 1 N HCl was added to the residue. The precipitate was filtered off and dried to yield 80 mg (85%) of the title compound. MS 424.15 (M+H)+,

Provenance & Evidence