Water → HCID 25110832, compound

HRID 604250Notes

Reaction equation

HRID 604250 reaction equation
C[O:2][C:3](=[O:38])/[CH:4]=[CH:5]/[C:6]1[C:10]([C:11](=[O:30])[C:12](=[O:29])[N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)[CH2:15][CH2:14]2)=[C:9]([CH3:31])[NH:8][C:7]=1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.[OH-].[Na+].O>C(O)C>[CH3:31][C:9]1[NH:8][C:7]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:38])=[O:2])[C:10]=1[C:11](=[O:30])[C:12](=[O:29])[N:13]1[CH2:18][CH2:17][N:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=2)[CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 25134066HCID 25134066, compound

Product 1

HCID 25110832HCID 25110832, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 155 mg (0.295 mmol) (E)-3-(5-methyl-4-{2-oxo-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-acetyl}-2-phenyl-1H-pyrrol-3-yl)-acrylic acid methyl ester in 2 ml ethanol 12 mg ((0.295 mmol) sodium hydroxide and 0.5 ml water were added. The mixture was stirred for 24 h at RT. The solvent was evaporated and the residue was treated with 1N HCl. The precipitate was filtered off and dried to give 120 mg (80%) of the title compound. MS 512.17 (M+H)+.

Workup

  1. customThe solvent was evaporated
  2. additionthe residue was treated with 1N HCl
  3. filtrationThe precipitate was filtered off
  4. customdried

Sources & evidence

ORD record
ord-dcadc47177474caeb0c2e369227a704e
Source dataset
uspto-grants-2011_03
Patent number
US07910576B2

Reaction notes

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