Water → HCID 25110832, compound

Participants

Reaction Steps

To a solution of 155 mg (0.295 mmol) (E)-3-(5-methyl-4-{2-oxo-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-acetyl}-2-phenyl-1H-pyrrol-3-yl)-acrylic acid methyl ester in 2 ml ethanol 12 mg ((0.295 mmol) sodium hydroxide and 0.5 ml water were added. The mixture was stirred for 24 h at RT. The solvent was evaporated and the residue was treated with 1N HCl. The precipitate was filtered off and dried to give 120 mg (80%) of the title compound. MS 512.17 (M+H)+.

Provenance & Evidence