HRID6043

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13394

m-Hydroxybenzonitrile

C7H5NO

结构：CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@@H](Br)SC[C@H]1OC(C)=O

HCID10926314

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1cccc(C#N)c1

HCID15067856

未命名化合物

收率 33.3%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID3007855

Zinc chloride

Cl2Zn

催化剂HCID10931941

未命名化合物

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

If the procedure described in Preparation LXXXIII is followed starting from 2 g (16.8.10-3 mol) of 3-hydroxybenzonitrile, 2.9 mg (16.5.10-3 mol) of silver imidazolate, 6.5 g (18.3.10-3 mol) of 2,3,4-tri-O-acetyl-5-thio-α-D-xylopyranosyl bromide and 4.6 g (33.6.10-3 mol) of zinc chloride in 80 ml of methylene chloride, 2.2 g (yield: 33%) of the expected product are obtained after purification by chromatography on silica gel using a hexane/ethyl acetate mixture (3/1 v/v) as the eluent, and precipitation in ether.

WORKUP

后处理

customIf the procedure described in Preparation LXXXIII