Lithium Hydroxide → 2-Bromo-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-7-carboxylic acid

HRID 604367Notes

Reaction equation

HRID 604367 reaction equation
[Br:1][C:2]1[S:14][C:13]2[C:12]3[CH:11]=[CH:10][C:9]([C:15]([O:17]C)=[O:16])=[CH:8][C:7]=3[NH:6][C:5](=[O:19])[C:4]=2[CH:3]=1.CO.C1COCC1.O.[Li+].[OH-]>O>[Br:1][C:2]1[S:14][C:13]2[C:12]3[CH:11]=[CH:10][C:9]([C:15]([OH:17])=[O:16])=[CH:8][C:7]=3[NH:6][C:5](=[O:19])[C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 3939Lithium HydroxideHCID 21892291Methanol tetrahydrofuran waterHCID 57500654Methyl 2-bromo-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-7-carboxylate

Product 1

HCID 575006552-Bromo-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-7-carboxylic acidYield 13%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Methyl 2-bromo-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-7-carboxylate (1.0 eq, 17 mg, 0.050 mmol) was suspended in a 1:1:1 mixture of MeOH/THF/water (0.6 ml). LiOH (39 mg) was added and the mixture stirred at room temperature for one hour. Water and 6NHCl was added and the resulting precipitate was filtered. The material was purified by preparative HPLC. Genevac evaporation provided 2-bromo-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-7-carboxylic acid as a solid (2.1 mg, 13% yield). LCMS (ES): >95% pure, m/z 324 [M]+, 326[M+2]+; 1H NMR (DMSO-d6, 400 MHz) δ 7.75 (s, 1H), 7.75 (dd, J=1.6, J=8.0, 1H), 7.90 (d, J=8.4, 1H), 8.03 (d, J=1.6, 1H), 12.06 (s, 1H) ppm.

Workup

  1. filtrationthe resulting precipitate was filtered
  2. customThe material was purified by preparative HPLC
  3. customGenevac evaporation

Sources & evidence

ORD record
ord-5423f45479144982b7865cdf8aac3378
Source dataset
uspto-grants-2011_03
Patent number
US07910600B2

Reaction notes

Loading…