反应详情

To a solution of 1 g 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-ethyl ester in 15 ml THF 314 mg LiBH4 were added cautiously. Then the reaction mixture was stirred for 16 h, quenched with diluted HCl and filtered through a Chem Elut® cartridge by elution with ethyl acetate and DCM. After concentration under reduced pressure the crude residue was directly subjected to the next reaction step.

1. customquenched with diluted HCl
2. filtrationfiltered through a Chem Elut® cartridge by elution with ethyl acetate and DCM
3. concentrationAfter concentration under reduced pressure the crude residue
4. customwas directly subjected to the next reaction step