反应详情

[5-(3-Methyl-[1,2,4]oxadiazol-5-yl)-4-phenyl-thiazol-2-yl]-carbamic acid tert-butyl ester was suspended in glacial acetic acid (20 mL). TFA (20 mL) was added. The reaction mixture was stirred at room temperature overnight. The reaction mixture was added to brine (100 mL) and pH was adjusted to pH 10 with ammonia. The mixture was extracted with EtOAc (2×75 mL). The combined organic phases was washed with brine (50 mL), dried with MgSO4 and solvents were removed in vacuo to give a white solid. Yield 98%.

1. extractionThe mixture was extracted with EtOAc (2×75 mL)
2. washThe combined organic phases was washed with brine (50 mL)
3. dry with materialdried with MgSO4 and solvents
4. customwere removed in vacuo
5. customto give a white solid