反应详情

2-Amino-4-phenyl-thiazole-5-carboxylic acid ethyl ester (5.0 g, 20 mmol) was suspended in methanol. Hydrazine monohydrate (5 mL, 100 mmol) was added and heated to reflux for 2 h. Hydrazine monohydrate (10 mL) was added and heated to reflux for 48 h. Water (100 mL) was added to the reaction mixture and the methanol was removed by evaporation in vacuo. The product precipitates and the solid product is collected by filtration. Yield: 70%.

1. temperatureheated
2. temperatureto reflux for 2 h
3. temperatureheated
4. temperatureto reflux for 48 h
5. customthe methanol was removed by evaporation in vacuo
6. customThe product precipitates
7. filtrationthe solid product is collected by filtration