Fumaric Acid → 1192731-63-7

HRID 604540Notes

Reaction equation

HRID 604540 reaction equation
C(O)(=O)/C=C/C(O)=O.Cl.[NH2:10][C@:11]([CH3:34])([CH2:14][CH2:15][C:16]1[N:17]([CH3:33])[C:18]([C:21](=[O:32])[CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=2)=[CH:19][CH:20]=1)[CH2:12][OH:13]>C(O)C>[NH2:10][C@:11]([CH3:34])([CH2:14][CH2:15][C:16]1[N:17]([CH3:33])[C:18]([C:21](=[O:32])[CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=2)=[CH:19][CH:20]=1)[CH2:12][OH:13]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 67039864HCID 67039864, compound

Product 1

HCID 113712901192731-63-7Yield 113.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Fumaric acid (94.9 mg, 0.82 mmol) was added to a solution of (2R)-2-amino-2-methyl-4-{1-methyl-5-[4-(4-methylphenyl)butanoyl]pyrrol-2-yl}butan-1-ol (560 mg, 1.6 mmol) obtained in Example 1 (1b) in ethanol (18 mL) at room temperature and the mixture was left to stand for 15 hours. The precipitated crystal was collected by filtration to obtain the title compound (622.7 mg, yield: 95%).

Workup

  1. waitthe mixture was left
  2. filtrationThe precipitated crystal was collected by filtration

Sources & evidence

ORD record
ord-b4441d6fbb3f4fd08414e0635623256f
Source dataset
uspto-grants-2011_03
Patent number
US07910617B2

Reaction notes

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