反应详情

温度

80 °C

(1-Methylpyrrol-2-yl)methyltrimethylammonium iodide (55.3 g, 198 mmol) was suspended in acetonitrile (400 mL) and triphenylphosphine (62.2 g, 237 mmol) was added thereto, followed by stirring of the mixture at 80° C. for 10 hours. After cooling, the mixture was concentrated to about 1/2 under reduced pressure, ethyl acetate (200 mL) was added thereto, and the precipitated crystal was collected by filtration. The crystal was washed with ethyl acetate and dried under reduced pressure to obtain the title compound (77.1 g, yield: 81%).

1. temperatureAfter cooling
2. concentrationthe mixture was concentrated to about 1/2 under reduced pressure, ethyl acetate (200 mL)
3. additionwas added
4. filtrationthe precipitated crystal was collected by filtration
5. washThe crystal was washed with ethyl acetate
6. customdried under reduced pressure