反应详情

2-t-Butoxycarbonylamino-2-ethylpropane-1,3-diol (52.9 g, 241 mmol) was suspended in isopropyl ether (1.0 L) and vinyl hexanoate (41.0 mL, 254 mmol) and lipase [Immobilized lipase from Pseudomonas sp., manufactured by TOYOBO Limited, 0.67 U/mg] (2.1 g) was added thereto, followed by stirring of the mixture at room temperature for 4 hours. After the reaction mixture was filtered, the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate, 7:1-4:1-2:1) to obtain the title compound (66.8 g, yield: 87%).

1. filtrationAfter the reaction mixture was filtered
2. customthe filtrate was evaporated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate, 7:1-4:1-2:1)