反应详情

温度

80 °C

(1-Ethylpyrrol-2-yl)methyltrimethylammonium iodide (20.0 g, 68.0 mmol) was suspended in acetonitrile (200 mL) and triphenylphosphine (22.0 g, 83.9 mmol) was added thereto, followed by stirring of the mixture at 80° C. for 9 hours. After cooling, the mixture was concentrated to about ½ under reduced pressure and ethyl acetate (100 mL) was added thereto. The precipitated crystal was collected by filtration, washed with ethyl acetate and dried under reduced pressure to obtain the title compound (27.5 g, yield: 81%).

1. temperatureAfter cooling
2. concentrationthe mixture was concentrated to about ½ under reduced pressure and ethyl acetate (100 mL)
3. additionwas added
4. filtrationThe precipitated crystal was collected by filtration
5. washwashed with ethyl acetate
6. customdried under reduced pressure