反应详情

30.1 g (151 mmol) of (3-bromophenyl)methyl ketone and 13.8 g (222 mmol) of ethylene glycol are dissolved in 120 mL of benzene, mixed with 60 mg of 4-toluenesulphonic acid and boiled under reflux at a water separator (Dean-Stark apparatus) until no more water is separated off. The reaction solution is washed with 50 mL of a 0.5 M NaHCO3 solution, the organic phase is separated off and dried over anhydrous MgSO4. After removal of the benzene in a rotary evaporator, the residue becomes the product with a purity (GC) of 97% in nearly quantitative yield as colorless oily liquid. C10H11O2Br.

1. customis separated off
2. washThe reaction solution is washed with 50 mL of a 0.5 M NaHCO3 solution
3. customthe organic phase is separated off
4. dry with materialdried over anhydrous MgSO4
5. customAfter removal of the benzene
6. customin a rotary evaporator