Hydrochloric Acid → HCID 23102719, compound

Participants

Reaction Steps

N-t-butoxycarbonylpiperidin-4-one and n-butylamine were subjected to reductive alkylation in acetic acid and dimethylformamide at room temperature using sodium triacetoxyborohydride. The obtained 1-t-butoxycarbonyl-4-aminopiperidine was reacted with 2,4-difluorobenzenisocyanate in dimethylformamide in the presence of triethylamine. The reaction mixture was deprotected by treatment with Hydrochloric acid to give N-butyl-N′-(2,4-difluorophenyl)-N-piperidin-4-ylurea hydrochloride. By the same procedure as described in Example 1 and the conversion to hydrochloride salt by a conventional method, using N-butyl-N′-(2,4-difluorophenyl)-N-piperidin-4-ylurea and 4-(4-formylphenoxy)benzoic acid, the compound of the present invention (48 mg) having the following physical data was obtained.

Provenance & Evidence