4-(Trifluoromethyl)aniline → HCID 67039045, compound

HRID 604953Notes

Reaction equation

HRID 604953 reaction equation
[C:1](=[O:8])([O:3][C:4](C)([CH3:6])[CH3:5])[NH2:2].C(=O)(O[C:12]([CH3:15])([CH3:14])[CH3:13])N.[F:17][C:18]([F:27])([F:26])[C:19]1[CH:25]=CC(N)=C[CH:20]=1>O1CCCC1>[C:1](=[O:8])([O:3][C:4]1[CH:6]=[CH:20][C:19]([C:18]([F:17])([F:26])[F:27])=[CH:25][C:5]=1[C:12]([CH3:15])([CH3:14])[CH3:13])[NH2:2]

Participants

4

Reactant 2

HCID 99644-(Trifluoromethyl)anilineHCID 86591668HCID 86591668, compound

Product 1

HCID 67039045HCID 67039045, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

First, di-tert-butyl dicarbamate (30 mL) was added to a tetrahydrofuran (50 mL) solution of 4-trifluoromethylaniline (10 mL). The reaction mixture was then refluxed for 10 hours. The solvent was distilled off under reduced pressure. Water was added to the residue to solidify the resulting product. The product was then washed with hexane. The title compound (18.7 g) was obtained as colorless crystals.

Workup

  1. temperatureThe reaction mixture was then refluxed for 10 hours
  2. distillationThe solvent was distilled off under reduced pressure
  3. additionWater was added to the residue
  4. washThe product was then washed with hexane

Sources & evidence

ORD record
ord-62cce0fa1ca54ac4a59eac918a938944
Source dataset
uspto-grants-2011_03
Patent number
US07910751B2

Reaction notes

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