3-Hydroxybenzyl alcohol → 3-(Bromomethyl)phenol

HRID 604958Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 604958
O[CH2:2][C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.ClCCl.C(Br)(Br)(Br)[Br:14]>C(#N)C>[Br:14][CH2:2][C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 1023-Hydroxybenzyl alcoholHCID 6344DichloromethaneHCID 11205Carbon tetrabromide

Produkt 1

HCID 137401503-(Bromomethyl)phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
2.5 °C

Versuchsvorschrift

3-[(Hydroxy)methyl]phenol was dissolved in acetonitrile (300 ml) and dichloromethane (900 ml) and the resulting mixture was poured in the flask kept under argon; magnetic stirring was set on. The solution was then cooled with an ice bath and carbon tetrabromide and triphenilphosphine were added. The latter was added in small portions in order to maintain the temperature at ca. 2-3° C.

Aufarbeitung

  1. temperatureThe solution was then cooled with an ice bath
  2. additionThe latter was added in small portions in order

Quellen und Nachweise

ORD-Eintrag
ord-dbdd56d5330447f5817756a27de14d87
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910767B2

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