HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 4-(4-Methoxy-phenylsulfanyl)-3-nitro-benzoic acid methyl ester | HCID 4166429 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester | HCID 61305583 | 90% |
Reaction Steps
To a solution of the product from Example 136A, iron powder and ammonium chloride in a methanol, tetrahydrofuran, and water solution was heated to reflux. The resultant mixture was filtered, and the filtrate was concentrated. Then ethyl acetate was added, stirred, filtered and concentrated under vacuum to provide the title compound (7.16 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07910595B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-4a25c8226a654b51b38d63a38d6243fc |
| Source note | uspto-grants-2011_03 |