3-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-N-p-tolyl-benzamide → N-(2-Hydroxy-phenyl)-4-(4-hydroxy-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

Participants

Reaction Steps

The product from Example 143 was reacted according to the procedure from Example 150 substituting the product from Example 143 for the product from Example 138 to provide a residue which was purified by trituration with methanol and diethyl ether to provide the title compound (26 mg, 55%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.37 (d, J=6.99 Hz, 6H), 3.21-3.43 (m, 1H), 6.83 (s, 1H), 6.84 (d, J=8.82 Hz, 2H), 6.92 (d, J=8.09 Hz, 1H), 7.02 (d, J=8.09 Hz, 2H), 7.32 (d, J=8.46 Hz, 2H), 7.63 (d, J=8.09 Hz, 1H), 7.93 (dd, J=8.46, 1.84 Hz, 1H), 7.99 (s, 1H), 8.94 (s, 1H), 9.08 (d, J=8.46 Hz, 1H), 9.51 (s, 1H), 9.74 (s, 1H), 10.02 (s, 1H); MS (APCI) m/z 524 (M+H)+.

Provenance & Evidence