Ammonium Chloride → HCID 67040778, compound

HRID 605223Notes

Reaction equation

HRID 605223 reaction equation
[Cl:1][C:2]([Cl:38])([Cl:37])[CH2:3][O:4][C:5](=[O:36])[NH:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:32])[N:21]([C:25]3[CH:30]=[CH:29][C:28]([Br:31])=[CH:27][CH:26]=3)[CH:22]([CH3:24])[CH3:23])=[CH:16][C:15]=2[N+:33]([O-])=O)=[CH:9][CH:8]=1.[NH4+].[Cl-]>[Fe]>[Cl:37][C:2]([Cl:1])([Cl:38])[CH2:3][O:4][C:5](=[O:36])[NH:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:32])[N:21]([C:25]3[CH:26]=[CH:27][C:28]([Br:31])=[CH:29][CH:30]=3)[CH:22]([CH3:24])[CH3:23])=[CH:16][C:15]=2[NH2:33])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 67040126HCID 67040126, compound

Product 1

HCID 67040778HCID 67040778, compoundYield 53.7%

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

The product from Example 208A (0.6428 mmol) was reduced with Fe and NH4Cl following the procedure from Example 9E to yield the title compound (218 mg, 53% yield) as an off white solid.

Sources & evidence

ORD record
ord-d066ea29ecae4c32a360d84b70c66e17
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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