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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 605235Generated: October 25, 2026

2-Amino-5-(trifluoromethyl)pyridine → 4-Fluoro-3-nitro-N-(5-trifluoromethyl-pyridin-2-yl)-benzamide

https://huagongshe.com/reaction/605235

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-5-(trifluoromethyl)pyridineHCID 735862—
Reactant4-Fluoro-3-nitrobenzoyl chlorideHCID 2783347—
Product4-Fluoro-3-nitro-N-(5-trifluoromethyl-pyridin-2-yl)-benzamideHCID 67040536100%

Reaction Steps

The product from Example 172a was reacted with 5-trifluoromethyl-pyridin-2-ylamine (239 mg, 1.474 mmol) according to the procedure from Example 172b to provide the title compound (485 mg, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07910595B2
Source datasetuspto-grants-2011_03
ORD IDord-63eec418818c407a8c04c5793a596bc6
Source noteuspto-grants-2011_03