2-Amino-5-(trifluoromethyl)pyridine → 4-Fluoro-3-nitro-N-(5-trifluoromethyl-pyridin-2-yl)-benzamide

HRID 605235Notes

Reaction equation

HRID 605235 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[F:14][C:15]([F:24])([F:23])[C:16]1[CH:17]=[CH:18][C:19]([NH2:22])=[N:20][CH:21]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:22][C:19]2[CH:18]=[CH:17][C:16]([C:15]([F:23])([F:14])[F:24])=[CH:21][N:20]=2)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

3

Reactant 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 27833474-Fluoro-3-nitrobenzoyl chloride

Product 1

HCID 670405364-Fluoro-3-nitro-N-(5-trifluoromethyl-pyridin-2-yl)-benzamideYield 100%

Procedure

The product from Example 172a was reacted with 5-trifluoromethyl-pyridin-2-ylamine (239 mg, 1.474 mmol) according to the procedure from Example 172b to provide the title compound (485 mg, 100%).

Sources & evidence

ORD record
ord-63eec418818c407a8c04c5793a596bc6
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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