1,3,4-Thiadiazol-2-amine → 4-Fluoro-3-nitro-N-[1,3,4]thiadiazol-2-yl-benzamide

HRID 605237Notes

Reaction equation

HRID 605237 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[S:14]1[CH:18]=[N:17][N:16]=[C:15]1[NH2:19]>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:19][C:15]2[S:14][CH:18]=[N:17][N:16]=2)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

3

Reactant 2

HCID 199091,3,4-Thiadiazol-2-amineHCID 27833474-Fluoro-3-nitrobenzoyl chloride

Product 1

HCID 432166104-Fluoro-3-nitro-N-[1,3,4]thiadiazol-2-yl-benzamideYield 67%

Procedure

The product from Example 172a was reacted with [1,3,4]Thiadiazol-2-ylamine (149 mg, 1.474 mmol) according to the procedure from Example 172b to provide the title compound (272 mg, 67%).

Sources & evidence

ORD record
ord-ed2f5c9026ea4eb8a679630cac026aa2
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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