Hydrogen Bromide → HCID 67040294, compound

HRID 605239Notes

Reaction equation

C(OC(=O)[NH:10][C:11]1[CH:12]=[N:13][CH:14]=[C:15]([Br:17])[CH:16]=1)C1C=CC=CC=1.[BrH:19]>>[BrH:17].[BrH:19].[Br:17][C:15]1[CH:16]=[C:11]([NH2:10])[CH:12]=[N:13][CH:14]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 18446849Benzyl (5-bromopyridin-3-yl)carbamate

Product 1

HCID 67040294HCID 67040294, compound

Procedure

A suspension of the product of Example 231A (200 mg, 0.6512 mmol) in a hydrogen bromide solution (33 weight % HBr in acetic acid, 3 mL) was stirred at room temperature for 4 hours. The solvent was removed by rotary evaporation in vacuo and the residue azeotroped with dry toluene (10 mL) to afford the title compound as a light peach colored solid (205 mg, 94%).

Workup

customThe solvent was removed by rotary evaporation in vacuo
customthe residue azeotroped with dry toluene (10 mL)

Sources & evidence

ORD record: ord-e35fcc59c6924741908b16688acbbb6c
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07910595B2

Reaction notes

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