Hydroquinone → HCID 67041163, compound

HRID 605299Notes

Reaction equation

HRID 605299 reaction equation
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)[OH:2].F[C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:28])[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=2)=[CH:12][C:11]=1[N+:29]([O-:31])=[O:30]>O>[OH:2][C:1]1[CH:8]=[CH:7][C:5]([O:6][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:28])[C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=3)=[CH:12][C:11]=2[N+:29]([O-:31])=[O:30])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 785HydroquinoneHCID 2088519HCID 2088519, compound

Product 1

HCID 67041163HCID 67041163, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of hydroquinone was heated under a nitrogen atmosphere. A solution of the product from Example 114A was added dropwise. The mixture was then stirred, cooled, poured into water, and adjusted the pH. The mixture was extracted, washed, and concentrated to provide N-[4-(4-Hydroxy-phenoxy)-3-nitro-phenyl]-3-trifluoromethyl-benzamide which was reduced to provide the title product.

Workup

  1. temperaturecooled
  2. extractionThe mixture was extracted
  3. washwashed
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-8b39a7638e1b4cbb87488a220df6eb43
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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