反应详情

温度

0 °C

Pyridine (0.6 g, 7.6 mmol) was added to 6-amino-2-{[(1S)-1-phenylethyl]thio}pyrimidin-4-ol (1 g, 4 mmol) and KSCN (1.7 g, 16 mmol) in DMF (20 mL). The reaction mixture was cooled to 0° C. and bromine (0.65 g, 4.0 mmol) was then added in one portion. The reaction mixture was poured into water after 2 h and the orange precipitate was filtered off and washed with water. The solid was suspended in a mixture of DMF (6 mL) and water (2 mL) and heated to 110° C. After 30 h, the reaction mixture was poured into water, the yellowish precipitate was filtered off and washed with water and ether. The solid was dried in vacuum at 40° C. to give the title compound (0.8 g, 65% yield).

1. filtrationthe orange precipitate was filtered off
2. washwashed with water
3. additionThe solid was suspended in a mixture of DMF (6 mL) and water (2 mL)
4. temperatureheated to 110° C
5. additionthe reaction mixture was poured into water
6. filtrationthe yellowish precipitate was filtered off
7. washwashed with water and ether
8. customThe solid was dried in vacuum at 40° C.