HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 2-Amino-2-methylpropyl di-tert-butyl phosphate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Benzyl 1-(di-tert-butoxyphosphoryloxy)-2-methylpropan-2-ylcarbamate | HCID 67040944 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-2-methylpropyl di-tert-butyl phosphate | HCID 86615566 | 94.8% |
Reaction Steps
The product of Example 438B (0.40 g, 0.96 mmol) and 20% palladium hydroxide on carbon (0.21 g) in a ethyl acetate (10 mL) and methanol (1 mL) was stirred under a an atmosphere of hydrogen for 0.5 hours. The reaction was filtered through a bed of celite and concentrate to give the title product (0.256 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07910595B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-0ca34fa600a14f619a419228036ed51c |
| Source note | uspto-grants-2011_03 |