3-(7-Isopropylpyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-(methoxycarbonylamino)phenylthio)benzoic acid → Methyl 4-(4-(1-(di-tert-butoxyphosphoryloxy)-2-phenylpropan-2-ylcarbamoyl)-2-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)phenylthio)phenylcarbamate

HRID 605408Notes

Reaction equation

HRID 605408 reaction equation
[P:1]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])([O:3][CH2:4][C:5]([NH2:13])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:6])=[O:2].[CH:24]([C:27]1[CH:28]=[CH:29][C:30]2[C:35]([NH:36][C:37]3[CH:38]=[C:39]([CH:43]=[CH:44][C:45]=3[S:46][C:47]3[CH:52]=[CH:51][C:50]([NH:53][C:54]([O:56][CH3:57])=[O:55])=[CH:49][CH:48]=3)[C:40](O)=[O:41])=[N:34][CH:33]=[N:32][C:31]=2[N:58]=1)([CH3:26])[CH3:25]>>[C:20]([O:19][P:1]([O:3][CH2:4][C:5]([NH:13][C:40]([C:39]1[CH:43]=[CH:44][C:45]([S:46][C:47]2[CH:48]=[CH:49][C:50]([NH:53][C:54](=[O:55])[O:56][CH3:57])=[CH:51][CH:52]=2)=[C:37]([NH:36][C:35]2[C:30]3[CH:29]=[CH:28][C:27]([CH:24]([CH3:26])[CH3:25])=[N:58][C:31]=3[N:32]=[CH:33][N:34]=2)[CH:38]=1)=[O:41])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:6])([O:14][C:15]([CH3:16])([CH3:18])[CH3:17])=[O:2])([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 670408713-(7-Isopropylpyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-(methoxycarbonylamino)phenylthio)benzoic acidHCID 670410332-Amino-2-phenylpropyl di-tert-butyl phosphate

Product 1

HCID 67040468Methyl 4-(4-(1-(di-tert-butoxyphosphoryloxy)-2-phenylpropan-2-ylcarbamoyl)-2-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)phenylthio)phenylcarbamateYield 43%

Procedure

The title compound was prepared (yield 43%) by the procedure of Example 441E substituting the product of Example 442C for the product of Example 441D.

Sources & evidence

ORD record
ord-3c2bdd458e9648ec8332772e7d5f6a5c
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

Loading…