3-(7-Isopropylpyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-(methoxycarbonylamino)phenylthio)benzoic acid → Methyl 4-(4-(1-(di-tert-butoxyphosphoryloxy)-2-phenylpropan-2-ylcarbamoyl)-2-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)phenylthio)phenylcarbamate

Participants

Role	Name	HCID	Charge
Reactant	3-(7-Isopropylpyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-(methoxycarbonylamino)phenylthio)benzoic acid	HCID 67040871	—
Reactant	2-Amino-2-phenylpropyl di-tert-butyl phosphate	HCID 67041033	—
Product	Methyl 4-(4-(1-(di-tert-butoxyphosphoryloxy)-2-phenylpropan-2-ylcarbamoyl)-2-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)phenylthio)phenylcarbamate	HCID 67040468	43%

Reaction Steps

The title compound was prepared (yield 43%) by the procedure of Example 441E substituting the product of Example 442C for the product of Example 441D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07910595B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-3c2bdd458e9648ec8332772e7d5f6a5c
Source note	uspto-grants-2011_03