HCID 67040380, compound → HCID 67041190, compound

HRID 605420Notes

Reaction equation

[F:1][CH2:2][C@H:3]([NH:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([S:19][C:20]2[CH:25]=[CH:24][C:23]([NH:26]C(=O)OC(C)(C)C)=[CH:22][CH:21]=2)=[C:15]([NH:34][C:35]2[C:36]3[CH:44]=[CH:43][C:42]([CH:45]([CH3:47])[CH3:46])=[N:41][C:37]=3[N:38]=[CH:39][N:40]=2)[CH:14]=1)=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(OC(=O)NC1C=CC(SC2C=CC(C(=O)N[C@H](C3C=CC=CC=3)C)=CC=2NC2C3C=CC(C(C)C)=NC=3N=CN=2)=CC=1)(C)(C)C>>[NH2:26][C:23]1[CH:24]=[CH:25][C:20]([S:19][C:16]2[CH:17]=[CH:18][C:13]([C:11]([NH:10][C@H:3]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:2][F:1])=[O:12])=[CH:14][C:15]=2[NH:34][C:35]2[C:36]3[CH:44]=[CH:43][C:42]([CH:45]([CH3:47])[CH3:46])=[N:41][C:37]=3[N:38]=[CH:39][N:40]=2)=[CH:21][CH:22]=1

Participants

Reactant 2

HCID 67040380HCID 67040380, compound

HCID 86615569HCID 86615569, compound

Product 1

HCID 67041190HCID 67041190, compoundYield 71%

Procedure

The title compound was prepared (yield 71%) by the procedure of Example 385G substituting the product of Example 448B for the product of Example 385F. 1H-NMR (300 MHz, DMSO-d6) δ ppm: 1.34 (d, J=7.0 Hz, 6H), 3.23 (septet, J=7.0 Hz, 1H), 4.48-4.79 (m, 2H), 5.32-5.49 (m, 1H), 6.62 (d, J=8.5 Hz, 2H), 6.86 (d, J=8.4 Hz, 1H), 7.13 (d, J=8.5 Hz, 2H), 7.28 (t, J=7.0 Hz, 1H), 7.35 (t, J=7.0 Hz, 2H), 7.43 (d, J=7.0 Hz, 2H), 7.68 (d, J=8.1 Hz, 1H), 7.73 (br-d, J=8.4 Hz, 1H), 7.88 (br-s, 1H), 8.61 (br-s, 1H), 8.89 (d, J=8.1 Hz, 1H), 9.00 (d, J=8.1 Hz, 1H), 10.45 (br-s, 1H) MS ESI+ m/z: 553 (M+H), ESI− m/z: 551 (M+H).

Sources & evidence

ORD record: ord-a40787d55ea746bb96a55cac12f12785
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07910595B2

Reaction notes

Loading…