Sodium Hydroxide → HCID 57627709, compound

HRID 605435Notes

Reaction equation

HRID 605435 reaction equation
CC1[O:3][CH2:4][CH2:5][C:6]([CH3:14])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[OH-].[Na+]>CO>[NH2:7][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:14])[CH2:5][CH2:4][OH:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 576242HCID 576242, compound

Product 1

HCID 57627709HCID 57627709, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

The product of Example 457D (0.886 g, 4.68 mmol) in methanol (15 ml) at room temperature was reacted with 6N NaOH (15 ml) and the resulting mixture heated under nitrogen at 80° C. overnight. The methanol was evaporated in vacuo and the aqueous residue isolated by extraction with dichloromethane. The combined extracts were dried over sodium sulfate and concentrated in vacuo to give the title compound (0.717 g, 93%) as a pale yellow solid used without further purification.

Workup

  1. customThe methanol was evaporated in vacuo
  2. customthe aqueous residue isolated by extraction with dichloromethane
  3. dry with materialThe combined extracts were dried over sodium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e92bebb1ec694644bf1488c8be65c7bf
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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