Sodium Hydroxide → HCID 57627709, compound

Participants

Reaction Conditions

Reaction Steps

The product of Example 457D (0.886 g, 4.68 mmol) in methanol (15 ml) at room temperature was reacted with 6N NaOH (15 ml) and the resulting mixture heated under nitrogen at 80° C. overnight. The methanol was evaporated in vacuo and the aqueous residue isolated by extraction with dichloromethane. The combined extracts were dried over sodium sulfate and concentrated in vacuo to give the title compound (0.717 g, 93%) as a pale yellow solid used without further purification.

Provenance & Evidence