Methyl chloroformate → HCID 178502065, compound

To a solution of 5-Amino tetrazole (10.00 g, 117.56 mmol)/Triethyl amine (16.48 ml, 118.739 mmol) in acetonitrile was added Methyl chloroformate (9.1375 ml, 118.739 mmol) at 0° C. The reaction mixture was slowly brought to room temperature and stirred for about 30 minutes. After about 30 minutes the reaction warmed and was refluxed for about 2 hrs. The reaction was then cooled to room temperature and the solvent was removed under reduced pressure, leaving a residue. The residue was washed with dilyte HCl to yield a white-colored solid. The solid was then dried at 105 C for about 6 hrs, resulting in a 92% yield.

1. customwas slowly brought to room temperature
2. temperatureAfter about 30 minutes the reaction warmed
3. temperaturewas refluxed for about 2 hrs
4. customthe solvent was removed under reduced pressure
5. customleaving a residue
6. washThe residue was washed with dilyte HCl
7. customto yield a white-colored solid
8. customThe solid was then dried at 105 C for about 6 hrs
9. customresulting in a 92% yield

ORD record

ord-9157ee50fb0545caae8292a05d8ccdd4

Source dataset

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07914632B2