Methanol → 3-[(3R,4R)-3,4-Dimethylpiperidin-4-yl]phenol

HRID 605446Notes

Reaction equation

HRID 605446 reaction equation
CO.O.[OH:4][C:5]1[CH:6]=[C:7]([C:11]2([CH3:30])[CH2:16][CH2:15][N:14](CC(CC3C=CC=CC=3)C(O)=O)[CH2:13][CH:12]2[CH3:29])[CH:8]=[CH:9][CH:10]=1>O>[CH3:29][C@@H:12]1[C@@:11]([C:7]2[CH:6]=[C:5]([OH:4])[CH:10]=[CH:9][CH:8]=2)([CH3:30])[CH2:16][CH2:15][NH:14][CH2:13]1

Participants

4

Reactant 2

HCID 887MethanolHCID 67690602HCID 67690602, compound

Product 1

HCID 110527673-[(3R,4R)-3,4-Dimethylpiperidin-4-yl]phenol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A beaker was charged with methanol (0.4 kg), water (0.5 L), and Compound 7(100 g). The mixture was charged to the reactor and rinsed forward with a solution of water (0.3 L) and methanol (0.2 kg) to seed the reaction mixture.

Workup

  1. additionThe mixture was charged to the reactor
  2. washrinsed forward with a solution of water (0.3 L) and methanol (0.2 kg) to seed the reaction mixture

Sources & evidence

ORD record
ord-45b3388f9abd4e1e8a39f2ff1324fc4d
Source dataset
uspto-grants-2011_03
Patent number
US07914776B2

Reaction notes

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