反应详情

31.2 g of N-methoxymethanamine hydrochloride and 91.2 ml of triethylamine in 500 ml of DCM is cooled in an ice bath, and then 56 g of 4-chlorobenzoyl chloride are added slowly and the mixture is left to stir at AT for 4 hours. A mixture of ice/water is added, the mixture is extracted with DCM, the organic phase is washed with a buffer solution pH=2 and dried over Na2SO4, and the solvent is evaporated off under vacuum. 60 g of the expected compound are obtained.

1. waitthe mixture is left
2. additionis added
3. extractionthe mixture is extracted with DCM
4. washthe organic phase is washed with a buffer solution pH=2
5. dry with materialdried over Na2SO4
6. customthe solvent is evaporated off under vacuum