反应详情

温度

0 °C

A mixture of 3 g of adamantan-1-ylmethanol and 5 ml of triethylamine in 50 ml of DCM is cooled to 0° C., 2 ml of methanesulfonyl chloride are added dropwise, and the mixture is left to stir while allowing the temperature to return to AT. A mixture of water/ice is added to the reaction mixture, the mixture is extracted with DCM, the organic phase is dried over Na2SO4, and the solvent is evaporated off under vacuum. 2 g of the expected compound are obtained.

1. waitthe mixture is left
2. additionis added to the reaction mixture
3. extractionthe mixture is extracted with DCM
4. dry with materialthe organic phase is dried over Na2SO4
5. customthe solvent is evaporated off under vacuum