tert-Butoxy bis(dimethylamino)methane → HCID 53423662, compound

HRID 605584Notes

Reaction equation

HRID 605584 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:4][CH:3]=1.C(O[CH:20](N(C)C)[N:21]([CH3:23])[CH3:22])(C)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:9](=[O:14])[C:10]([CH3:11])([CH3:13])[CH3:12])=[CH:20][N:21]([CH3:23])[CH3:22])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 101045691-(4-Chlorophenyl)-3,3-dimethylbutan-2-one

Product 1

HCID 53423662HCID 53423662, compound

Procedure

1-(4-Chlorophenyl)-3,3-dimethyl-butan-2-one (30 mmol) and tert-butoxybis-(dimethylamino)methane (31.5 mmol) are heated together at reflux overnight. The reaction mixture is then cooled to RT and the excess tert-butoxybis(dimethylamino)methane removed under reduced pressure to give 2-(4-chlorophenyl)-1-dimethylamino-4,4-dimethyl-pent-1-en-3-one.

Workup

  1. temperatureat reflux overnight
  2. customthe excess tert-butoxybis(dimethylamino)methane removed under reduced pressure

Sources & evidence

ORD record
ord-28901e7a217948939c71802d2eb0773b
Source dataset
uspto-grants-2011_03
Patent number
US07915264B2

Reaction notes

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